Home » Research chemicals » Research chemicals for sale

Buy Tramadol, buy Pseudoephedrine, buy Ketamine powderWhatsApp: +86 16723783307)

Research Chemicals For Sale

Buy Tramadol, Buy Pseudoephedrine, Buy Ketamine PowderWhatsApp: +86 16723783307)

US$ 220 - 2600 /Kilogram

Minimum Order 0 Kilograms

Place of Origin China

Lastest Update Jan 29 2021

Visited 447 views

Product Details

Product Research chemicals for sale

Catagory Other Environmental Products » Research chemicals

Price Rate USD 220 - 2600 /Kilogram

Minimum Order n/a

Supply Ability 200 Kilograms/ Month

Brand Ultram

Model 27203925

Packaging Organised and stealthy manner

Moq : 10g Tramadol/CAS ID 27203-92-5 Brand name Ultram n/a

Place of Origin China

Port Port of Qinhuangdao

Delivery Time 9 Day

Delivery Detail By SeaOther

Price Term FOB

Payment Term T/T

Lastest Update Jan 29 2021

Posted Date Jan 28 2021

Buy Tramadol, buy Pseudoephedrine, buy Ketamine powderWhatsApp: +86 16723783307)

Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of morphine.
Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist but also affects monoamines by modulating the effects of neurotransmitters involved in the modulation of pain such as serotonin and norepinpehrine which activate descending pain inhibitory pathways.13 Tramadol's effects on serotonin and norepinephrine mimic the effects of other SNRI antidepressants such as duloxetine and venlafaxine.
Tramadol exists as a racemic mixture consisting of two pharmacologically active enantiomers that both contribute to its analgesic property through different mechanisms and are also themselves metabolized into active metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor while (+)-tramadol inhibits serotonin reuptake and (-)-tramadol inhibits norepinephrine reuptake. These pathways are complementary and synergistic improving tramadol's ability to modulate the perception of and response to pain.1225
Tramadol has also been shown to affect a number of other pain modulators within the central nervous system as well as non-neuronal inflammatory markers and immune mediators.1718202616 Due to the broad spectrum of targets involved in pain and inflammation it's not surprising that the evidence has shown that tramadol is effective for a number of pain types including neuropathic pain post-operative pain lower back pain as well as pain associated with labour osteoarthritis fibromyalgia and cancer. Due to its SNRI activity tramadol also has anxiolytic antidepressant and anti-shivering effects which are all frequently found as comorbidities with pain.16
Similar to other opioid medications tramadol poses a risk for development of tolerance dependence and abuse. If used in higher doses or with other opioids there is a dose-related risk of overdose respiratory depression and death.2230 However unlike other opioid medications tramadol use also carries a risk of seizure and serotonin syndrome particularly if used with other serotonergic medications.

 

Buy Tramadol, buy Pseudoephedrine, buy Ketamine powderWhatsApp: +86 16723783307)
Research chemicals for sale - Research chemicals by Heibechems co., Ltd
.

Heibechems co., Ltd

no.111 xisanzhuang street shijiazhuang, China China

Contact Chu∗∗∗∗∗ LiPlease Login

Membership

Latest Login 1 years ago

Registration Jan 28 2021

Send Enquiry
Please Login

Related Products

Silyl Acrylate Self-polishing Resin ----SPSi-100

Silyl Acrylate Self-polishing Resin ----SPSi-100

USD 100 - 100 /Kilogram

ChinaChina

 ZINC ACRYLATE SELF-POLISHING POLYMER

ZINC ACRYLATE SELF-POLISHING POLYMER

USD 100 - 100 /Kilogram

ChinaChina

Research chemicals for sale

Research chemicals for sale

USD 220 - 2600 /Kilogram

ChinaChina

Research chemicals for sale

Research chemicals for sale

USD 220 - 6000 /Kilogram

ChinaChina

Research chemicals for sale

Research chemicals for sale

USD 300 - 2500 /Kilogram

ChinaChina

Research chemicals for sale

Research chemicals for sale

USD 250 - 1600 /Kilogram

ChinaChina